Paleolithic Ketogenic Diet

This page is dedicated to showcasing English-language research and content produced by the International Center for Medical Nutritional Intervention (ICMNI) clinic in Hungary, formerly known as Paleomedicina Hungary. The Paleolithic Ketogenic Diet is trademarked by ICMNI. This website is not affiliated with ICMNI, and as such, this page should be viewed solely as an introduction to their research. You should consult with ICMNI if you have interest in PKD, to ensure that the diet is implemented according to their standards.

To learn more about their services and programs, read additional content (including other languages), and schedule consultations here, visit their websites here:

• https://paleomedicina.com/en/

• https://nutriintervention.com/

• TOC

ICMNI

The International Center for Medical Nutritional Intervention (ICMNI) clinic, formerly known as Paleomedicina, is based in Budapest, Hungary. Led by Dr. Zsófia Clemens and Dr. Csaba Tóth, ICMNI formulated the Paleolithic Ketogenic Diet (PKD) and have used it exclusively in their clinic since 2013 to treat an extensive range of autoimmune and metabolic diseases, such as type I diabetes, type II diabetes, cancer, and Crohn’s disease.

A primary focus of the clinic is the link between intestinal permeability and chronic health conditions. PKD was formulated as a diet shown to decrease intestinal permeability, as measured by the PEG-400 test. Read about leaky gut here.

Websites:

• https://paleomedicina.com/en/
• https://nutriintervention.com/

Twitter:

• Dr. Zsófia Clemens: @clemenszsofia
• Dr. Csaba Tóth: @paleoketogenic

Facebook: https://www.facebook.com/paleomedicina/

Instagram:

• Dr. Zsófia Clemens: @zsofiaclemens
• Ancestral Carnivore: @ancestralcarnivore

YouTube:

• Paleomedicina

Protocol

• “Therapeutic Protocol of Paleomedicina Hungary”

  Paleolithic ketogenic diet (PKD): A diet covering and limited to our physiological needs
  We have developed the PKD in 2010-2011. Previously we have been using the paleolithic diet which proved to be ineffective in the vast majority of chronic conditions. We believe that the PKD is the only evolutionary adapted diet for humans. Rehabilitation of chronic diseases is most effective when the diet is limited to our real physiological needs. Eating fruits and vegetables does not form part of our physiological need but are associated with risks. Plant foods can only be regarded as ”relatively” safe and only when certain plant food items are consumed and only in limited amounts. The diet was derived from clinical evidence and was not primarily influenced by archeological or ethnographic evidence, given that the application of the diet is clinical too. Altogether clinical experience was derived from about 4000 patients.

  Characterizaton of the PKD

  • 70-100% animal based food, 0-30% plant based foods (in volume)
    
  • Animal foods include red and fatty meats, fat and offal preferably from pasture- raised animals
  • Fat:protein ratio about 2:1 (in grams)
  • No nitrates, nitrites or other additives in meat products
  • Plant foods only include fruits and ”paleolithic” vegetables from organic sources
  • No artificial sweeteners but honey is allowed in moderation
  • Black and herbal tea are excluded
  • Coffee is allowed only after full regeneration and in moderation
  • Eggs are initially excluded in those with highly elevated intestinal permeability and/or vaccines during the preceding 6 months

• “Paleolithic Ketogenic Diet, Paleolithic Ketogenic Diet Rules”

  This is a paywalled article written by Dr. Zsófia Clemens and Dr. Csaba Tóth that gives an overview of the history and practice of the paleolithic ketogenic diet. Proceeds go towards the ICNMI.

  Developing the paleolithic ketogenic diet has been a major milestone in nutritional science; using the paleolithic ketogenic diet has enabled us to reverse chronic internal diseases that are currently regarded as incurable.

  Much has been published about healthy diets in general, however our work differs from most of these publications in that ours is based largely on clinical experience. Some of our results with the paleolithic ketogenic diet have been published at scientific forums. Moreover, our activities are not limited to clinical work only; we are also very involved in research. Much emphasis is placed on intestinal permeability, including its development and its reversal by diet.

  As you can deduce from reading the above, the paleolithic ketogenic diet follows on from the work of several eminent scientists, physicians, medical anthropologists and biologists. The highly esteemed Paleomedicina center in Hungary is where we use the paleolithic ketogenic diet as a tool of evolutionary medicine.

Journal Articles

• Clemens, Z., & Tóth, C. (2016). Vitamin C and Disease: Insights from the Evolutionary Perspective. Journal of Evolution and Health, 1(1). https://doi.org/10.15310/2334-3591.1030
• Tóth, C., Dabóczi, A., Chanrai, M., & Clemens, Z. (2017). Comment on “Systematic Review: Isocaloric Ketogenic Dietary Regimes for Cancer Patients” by Erickson et al. Journal of Cancer Research and Treatment, 5(3), 86–88. https://doi.org/10.12691/jcrt-5-3-2
• Clemens, Z., dr., Dabóczi, A., dr., & Tóth, C., dr. (2018). The paleolithic ketogenic diet may ensure adequate serum magnesium levels. Journal of Evolution and Health, 2(2). https://doi.org/10.15310/2334-3591.1070
• Clemens, Z., & Tóth, C. (2019). Paleolithic ketogenic diet (PKD) in chronic diseases: Clinical and research data. Journal of Evolution and Health, 3(2). https://doi.org/10.15310/2334-3591.1115

Case Studies

• Epilepsy – Clemens, Z., Kelemen, A., Fogarasi, A., & Tóth, C. (2013). Childhood Absence Epilepsy Successfully Treated with the Paleolithic Ketogenic Diet. Neurology and Therapy, 2(1–2), 71–76. https://doi.org/10.1007/s40120-013-0013-2
• Lung cancer – Tóth, C., & Clemens, Z. (2014). Recurrent tumor of the main bronchus successfully managed with the paleolithic ketogenic diet. https://doi.org/10.13140/RG.2.2.23148.97921
• Type I Diabetes – Tóth, C., & Clemens, Z. (2015). A child with type 1 diabetes mellitus (T1DM) successfully treated with the Paleolithic ketogenic diet: A 19-month insulin-freedom. International Journal of Case Reports and Images, 6(12), 752. https://doi.org/10.5348/ijcri-2015121-cr-10582
• Gilbert’s Syndrome – Tóth, C., & Clemens, Z. (2015). Gilbert’s Syndrome Successfully Treated with the Paleolithic Ketogenic Diet. American Journal of Medical Case Reports, 3(4), 117–120. https://doi.org/10.12691/ajmcr-3-4-9
• Type II Diabetes – Tóth, C., & Clemens, Z. (2015). Successful treatment of a patient with obesity, type 2 diabetes and hypertension with the paleolithic ketogenic diet. International Journal of Case Reports and Images, 6(3), 161. https://doi.org/10.5348/ijcri-201530-cr-10491
• Crohn’s Disease – Tóth, C., Dabóczi, A., Howard, M., Miller, N. J., & Clemens, Z. (2016). Crohn’s disease successfully treated with the paleolithic ketogenic diet. International Journal of Case Reports and Images, 7(9), 570. https://doi.org/10.5348/ijcri-2016102-cr-10690
• Soft Palate Cancer – Tóth, C., & Clemens, Z. (2016). Halted Progression of Soft Palate Cancer in a Patient Treated with the Paleolithic Ketogenic Diet Alone: A 20-months Follow-up. American Journal of Medical Case Reports, 4(8), 288-292.
• Brain Cancer – Clemens, Z., Dabóczi, A., Schimmer, M., Barsi, P., & Tóth, C. (2017). Treatment of High-Grade Brain Tumor Using the Paleolithic Ketogenic Diet (PKD): Three Cases The Staffan Lindeberg Memorial Conference, Lisbon 2017.
• Rectal Cancer – Tóth, C., & Clemens, Z. (2017). Treatment of Rectal Cancer with the Paleolithic Ketogenic Diet: A 24-months Follow-up. American Journal of Medical Case Reports, 5(8), 205-216. https://doi.org/10.12691/ajmcr-5-8-3
• Cervical Intraepithelial Neoplasia (CIN) – Tóth, C., Schimmer, M., & Clemens, Z. (2018). Complete Cessation of Recurrent Cervical Intraepithelial Neoplasia (CIN) by the Paleolithic Ketogenic Diet: A Case Report. Journal of Cancer Research and Treatment, 6(1), 1-5. https://doi.org/10.12691/jcrt-6-1-1
• Glioblastoma – Tóth, C., Dabóczi, A., Chanrai, M., Schimmer, M., & Clemens, Z. (2019). 38-month long progression-free and symptom-free survival of a patient with recurrent glioblastoma multiforme: A case report of the Paleolithic Ketogenic Diet (PKD) used as a stand-alone treatment after failed standard oncotherapy. Preprints. 10.20944/preprints201912.0264.v1
• Cancer – Clemens, Z., Dabóczi, A., & Tóth, C. (2019). Paleolithic ketogenic diet (PKD) as a stand-alone therapy in cancer: Case studies. Unpublished. https://doi.org/10.13140/RG.2.2.28600.19208

Presentations

• “Clinical Experience and Research with the Paleolithic Ketogenic Diet (PKD) – 2010-2017” - Dr. Zsófia Clemens
• CarnivoryCon 2019: “Intestinal Permeability in Autoimmune Diseases and Cancer: Measurement, Results and Implications” - Dr. Zsófia Clemens
  • CarnivoryCon 2019: “Q&A - Session 1”
• Clinical Open Days 2018 [Paywalled]
  1. Andrea Dabóczi: Paleolithic ketogenic diet (PKD): Weight loss and cure in one blow. Three years’ experience in patient workshops
  2. László G. Boros: Glycogenic versus ketogenic metabolism: Medical perspectives
  3. Zoltán Simon: Treatment of panic disorder with the paleolithic ketogenic diet (PKD): a case study
  4. Zsófia Clemens: Type 1 Diabetes Mellitus: fasting and stimulated C-peptide
  5. Arjun Panesar: Big data to big impact
  6. Ian Lake: A journey on the road less travelled in Type 1 diabetes. Insights from dietary experiments.
  7. Zsófia Clemens: Vitamin and mineral supplements: Do we really need them on a full-value diet?
  8. Csaba Tóth: It’s time to cure cancer, autoimmune and other chronic diseases. Causes, pathophysiology and therapy
  9. Péter Merész: HPLC-RP analysis of polyethylene glycol (PEG 400) for measuring intestinal permeability
  10. Zsófia Clemens: Intestinal permeability: causes and its relevance to autoimmune diseases and cancer
  11. Amber O’Hearn: Personal experiences in long-term carnivorous eating: benefits beyond carbohydrate restriction
  12. Thomas Seyfried: Cancer as a mitochondrial metabolic disease: Implications for novel therapeutics (online presentation)
  13. Zsófia Clemens: Combating cancer: Paleolithic ketogenic diet (PKD) as a stand-alone therapy. Theory, practice and results.
  14. Csaba Tóth: The paleolithic ketogenic diet (PKD) is more effective than medicines in treating chronic internal diseases. The art of tapering preexisting medicines.
  15. Ferenc Nagy – Mária Schimmer: Paleolithic ketogenic diet: perspective from the kitchen
  16. Zsófia Clemens: Paleo, low-carb, ketogenic, GAPS, AIP: Choose what you want?
  17. Károly Nagy: Raw meat feeding of dogs
  18. Gianluca Bosetti: Ketogenic diet and sports nutrition: the advantages of carbs periodization

Blog Posts

• 2015-11-20 – “Crohn’s disease and the paleolithic ketogenic diet: a graduation thesis”
• 2016-02-20 – ‘Every patient that received my initial treatment passed away’ Interview with Andrew Scarborough
• 2016-09-13 – “Is jumping into cold water during hot weather dangerous or not?”
• 2016-10-18 – “Five-day paleolithic ketogenic program”
• 2016-12-30 – “Gallbladder attack, gallbladder stones or something else? Gallbladder symptoms on the Paleolithic diet?”
• 2017-03-31 - “Stone age diet and workout”
• 2017-07-06 – “What can teeth tell us of our evolutionary past: Interview with Peter Ungar”
• 2017-08-25 – “Therapeutic intermittent fasting. Is it really therapeutic?”
• 2017-11-25 – “The salt craze is up and running despite a feasible solution”
• 2018-01-10 – “The sunshine vitamin? Really? The true cause of vitamin D deficiency. Five practicable tips.”
• 2018-01-28 – “The brain researcher says Szent-Györgyi was wrong: It’s no use taking vitamin C”
• 2018-02-03 – “Vitamin C and cancer”
• 2018-02-28 – “Nitrates and Nitrites: Are they harmless?”
• 2018-03-05 – “Brain tumour (glioblastoma) and paleo-ketogenic diet”
• 2019-08-04 – “My change to a meat-based diet: An English class project”
• 2019-08-10 – “Brilliant scientific success! Type 1 diabetes has been overcome. There is only one question left: will Hungarian or French researchers take credit for this groundbreaking discovery?”
• 2019-11-20 – “Open letter to Professor Loren Cordain about Ketogenic and Paleolithic Diet(s)”
• 2020-01-17 - “Paleolithic ketogenic diet (PKD) efficacy and applicability: FAQ”
• 2020-02-28 - “PKD explained by 14-year-old Isabella”
• 2020-03-24 - “Possibilities of reducing the spread of the SARS-CoV-2 virus and increasing natural resistance to the disease via nutritional intervention”
• 2020-05-02 - “COVID-19 coronavirus and vitamin D”
• 2020-05-09 - “Honey is the only healthy sweetener, even for people with diabetes”
• 2020-05-17 - “Suicide rates among the First Nations in Canada are on the rise. Reasons and a possible solution.”
• 2020-07-22 - “PKD Questions and Answers - 1”
• 2020-07-29 - “PKD Questions and Answers - 2”
• 2020-11-05 - “Charismatic Youtube influencers and science. Is it a good combination or not?”
• 2021-02-03 - “Coffee consumption from the perspective of toxicology and nutrition. Let us see the facts.”
• 2021-02-17 - “The deeper meaning of PKD. Be careful, very hard!”
• 2021-06-08 - “The case of the best performing glioblastoma patient in the world and Frontiers in Nutrition”

Podcasts

• 2018-04-01 – Get Fit With Jodelle – “Dr. Zsofia Clemens - The True Paleolithic Ketogenic Diet” [iTunes] [YouTube]
• 2018-07-20 – The Nourished Caveman – “The Keto Paleo Life Interview with Zsofia Clemens” (Includes transcript) [YouTube]
• 2018-08-24 – The Human Performance Outliers Podcast – “Episode 35: Dr. Csaba Tóth”
• 2018-09-06 – Biohackers Lab – “Ep66: Paleo-Ketogenic Diet Benefits (+Advanced Tips) • Dr Zsófia Clemens PhD” (Includes detailed summary) [iTunes]
• 2018-12-11 – Ketogeek’s Podcast – “16. Dr. Zsófia Clemens” [iTunes] [YouTube]
• 2019-03-20 – The Human Performance Outliers Podcast – “Episode 84: Dr. Zsófia Clemens” [iTunes] [YouTube]
• 2019-08-21 – Peak Human – “Dr. Zsófia Clemens on How to Cure Almost Any Modern Disease Without Medicine” [iTunes]
• 2019-09-16 – Fundamental Health Podcast – “Zsófia Clemens on reversing Type 1 diabetes, Crohns, and cancer with a high fat, nose to tail carnivore diet” [iTunes]
• 2020-10-19 - Move Wild Podcast - “The Paleolithic Ketogenic Diet With Natalie Daniels” [iTunes]

Media

• December 15, 2016 – “In Depth: Ostracised by the medical community, Dr Csaba Tóth insists the paleo keto diet is a groundbreaking diabetes treatment”
  • Interview: “Is the paleolithic ketogenic diet a groundbreaking diabetes treatment?” [YouTube] [17:31]
• July 13, 2018 – “Interview with Dr. Csaba Tóth by Evolutamente.it”
• January 14, 2020 - “Dr Zsofia Clemens talks about her work with the PKD diet at the Spanish carnivore retreat 2019.” [YouTube] [20:03]