Paleolithic Ketogenic Diet
This page is dedicated to showcasing English-language research and content produced by the International Center for Medical Nutritional Intervention (ICMNI) clinic in Hungary, formerly known as Paleomedicina Hungary. The Paleolithic Ketogenic Diet is trademarked by ICMNI. This website is not affiliated with ICMNI, and as such, this page should be viewed solely as an introduction to their research. You should consult with ICMNI if you have interest in PKD, to ensure that the diet is implemented according to their standards.
To learn more about their services and programs, read additional content (including other languages), and schedule consultations here, visit their website here: https://paleomedicina.com/en/
The International Center for Medical Nutritional Intervention (ICMNI) clinic, formerly known as Paleomedicina, is based in Budapest, Hungary. Led by Dr. Zsófia Clemens and Dr. Csaba Tóth, ICMNI formulated the Paleolithic Ketogenic Diet (PKD) and have used it exclusively in their clinic since 2013 to treat an extensive range of autoimmune and metabolic diseases, such as type I diabetes, type II diabetes, cancer, and Crohn’s disease.
A primary focus of the clinic is the link between intestinal permeability and chronic health conditions. PKD was formulated as a diet shown to decrease intestinal permeability, as measured by the PEG-400 test.
- “Therapeutic Protocol of Paleomedicina Hungary”
Paleolithic ketogenic diet (PKD): A diet covering and limited to our
We have developed the PKD in 2010-2011. Previously we have been using the paleolithic diet which proved to be ineffective in the vast majority of chronic conditions. We believe that the PKD is the only evolutionary adapted diet for humans. Rehabilitation of chronic diseases is most effective when the diet is limited to our real physiological needs. Eating fruits and vegetables does not form part of our physiological need but are associated with risks. Plant foods can only be regarded as ”relatively” safe and only when certain plant food items are consumed and only in limited amounts. The diet was derived from clinical evidence and was not primarily influenced by archeological or ethnographic evidence, given that the application of the diet is clinical too. Altogether clinical experience was derived from about 4000 patients.
Characterizaton of the PKD
- 70-100% animal based food, 0-30% plant based foods (in volume)
- Animal foods include red and fatty meats, fat and offal preferably from pasture-
- Fat:protein ratio about 2:1 (in grams)
- No nitrates, nitrites or other additives in meat products
- Plant foods only include fruits and ”paleolithic” vegetables from organic sources
- No artificial sweeteners but honey is allowed in moderation
- Black and herbal tea are excluded
- Coffee is allowed only after full regeneration and in moderation
- Eggs are initially excluded in those with highly elevated intestinal permeability
and/or vaccines during the preceding 6 months
“Paleolithic Ketogenic Diet, Paleolithic Ketogenic Diet Rules”
This is a paywalled article written by Dr. Zsófia Clemens and Dr. Csaba Tóth that gives an overview of the history and practice of the paleolithic ketogenic diet. Proceeds go towards the ICNMI.
Developing the paleolithic ketogenic diet has been a major milestone in nutritional science; using the paleolithic ketogenic diet has enabled us to reverse chronic internal diseases that are currently regarded as incurable.
Much has been published about healthy diets in general, however our work differs from most of these publications in that ours is based largely on clinical experience. Some of our results with the paleolithic ketogenic diet have been published at scientific forums. Moreover, our activities are not limited to clinical work only; we are also very involved in research. Much emphasis is placed on intestinal permeability, including its development and its reversal by diet.
As you can deduce from reading the above, the paleolithic ketogenic diet follows on from the work of several eminent scientists, physicians, medical anthropologists and biologists. The highly esteemed Paleomedicina center in Hungary is where we use the paleolithic ketogenic diet as a tool of evolutionary medicine.
- Clemens, Z., & Tóth, C. (2016). Vitamin C and Disease: Insights from the Evolutionary Perspective. Journal of Evolution and Health, 1(1). https://doi.org/10.15310/2334-3591.1030
- Tóth, C., Dabóczi, A., Chanrai, M., & Clemens, Z. (2017). Comment on “Systematic Review: Isocaloric Ketogenic Dietary Regimes for Cancer Patients” by Erickson et al. Journal of Cancer Research and Treatment, 5(3), 86–88. https://doi.org/10.12691/jcrt-5-3-2
- Clemens, Z., dr., Dabóczi, A., dr., & Tóth, C., dr. (2018). The paleolithic ketogenic diet may ensure adequate serum magnesium levels. Journal of Evolution and Health, 2(2). https://doi.org/10.15310/2334-3591.1070
- Clemens, Z., & Tóth, C. (2019). Paleolithic ketogenic diet (PKD) in chronic diseases: Clinical and research data. Journal of Evolution and Health, 3(2). https://doi.org/10.15310/2334-3591.1115
- Epilepsy – Clemens, Z., Kelemen, A., Fogarasi, A., & Tóth, C. (2013). Childhood Absence Epilepsy Successfully Treated with the Paleolithic Ketogenic Diet. Neurology and Therapy, 2(1–2), 71–76. https://doi.org/10.1007/s40120-013-0013-2
- Lung cancer – Tóth, C., & Clemens, Z. (2014). Recurrent tumor of the main bronchus successfully managed with the paleolithic ketogenic diet. https://doi.org/10.13140/RG.2.2.23148.97921
- Type I Diabetes – Tóth, C., & Clemens, Z. (2015). A child with type 1 diabetes mellitus (T1DM) successfully treated with the Paleolithic ketogenic diet: A 19-month insulin-freedom. International Journal of Case Reports and Images, 6(12), 752. https://doi.org/10.5348/ijcri-2015121-cr-10582
- Gilbert’s Syndrome – Tóth, C., & Clemens, Z. (2015). Gilbert’s Syndrome Successfully Treated with the Paleolithic Ketogenic Diet. American Journal of Medical Case Reports, 3(4), 117–120. https://doi.org/10.12691/ajmcr-3-4-9
- Type II Diabetes – Tóth, C., & Clemens, Z. (2015). Successful treatment of a patient with obesity, type 2 diabetes and hypertension with the paleolithic ketogenic diet. International Journal of Case Reports and Images, 6(3), 161. https://doi.org/10.5348/ijcri-201530-cr-10491
- Crohn’s Disease – Tóth, C., Dabóczi, A., Howard, M., Miller, N. J., & Clemens, Z. (2016). Crohn’s disease successfully treated with the paleolithic ketogenic diet. International Journal of Case Reports and Images, 7(9), 570. https://doi.org/10.5348/ijcri-2016102-cr-10690
- Soft Palate Cancer – Tóth, C., & Clemens, Z. (2016). Halted Progression of Soft Palate Cancer in a Patient Treated with the Paleolithic Ketogenic Diet Alone: A 20-months Follow-up. American Journal of Medical Case Reports, 4(8), 288-292.
- Brain Cancer – Clemens, Z., Dabóczi, A., Schimmer, M., Barsi, P., & Tóth, C. (2017). Treatment of High-Grade Brain Tumor Using the Paleolithic Ketogenic Diet (PKD): Three Cases The Staffan Lindeberg Memorial Conference, Lisbon 2017.
- Rectal Cancer – Tóth, C., & Clemens, Z. (2017). Treatment of Rectal Cancer with the Paleolithic Ketogenic Diet: A 24-months Follow-up. American Journal of Medical Case Reports, 5(8), 205-216. https://doi.org/10.12691/ajmcr-5-8-3
- Cervical Intraepithelial Neoplasia (CIN) – Tóth, C., Schimmer, M., & Clemens, Z. (2018). Complete Cessation of Recurrent Cervical Intraepithelial Neoplasia (CIN) by the Paleolithic Ketogenic Diet: A Case Report. Journal of Cancer Research and Treatment, 6(1), 1-5. https://doi.org/10.12691/jcrt-6-1-1
- Glioblastoma – Tóth, C., Dabóczi, A., Chanrai, M., Schimmer, M., & Clemens, Z. (2019). 38-month long progression-free and symptom-free survival of a patient with recurrent glioblastoma multiforme: A case report of the Paleolithic Ketogenic Diet (PKD) used as a stand-alone treatment after failed standard oncotherapy. Preprints. 10.20944/preprints201912.0264.v1
- Cancer – Clemens, Z., Dabóczi, A., & Tóth, C. (2019). Paleolithic ketogenic diet (PKD) as a stand-alone therapy in cancer: Case studies. Unpublished. https://doi.org/10.13140/RG.2.2.28600.19208
- “Clinical Experience and Research with the Paleolithic Ketogenic Diet (PKD) – 2010-2017” - Dr. Zsófia Clemens
- CarnivoryCon 2019: “Intestinal Permeability in Autoimmune Diseases and Cancer: Measurement, Results and Implications” - Dr. Zsófia Clemens
- Clinical Open Days 2018 [Paywalled]
- Andrea Dabóczi: Paleolithic ketogenic diet (PKD): Weight loss and cure in one blow. Three years’ experience in patient workshops
- László G. Boros: Glycogenic versus ketogenic metabolism: Medical perspectives
- Zoltán Simon: Treatment of panic disorder with the paleolithic ketogenic diet (PKD): a case study
- Zsófia Clemens: Type 1 Diabetes Mellitus: fasting and stimulated C-peptide
- Arjun Panesar: Big data to big impact
- Ian Lake: A journey on the road less travelled in Type 1 diabetes. Insights from dietary experiments.
- Zsófia Clemens: Vitamin and mineral supplements: Do we really need them on a full-value diet?
- Csaba Tóth: It’s time to cure cancer, autoimmune and other chronic diseases. Causes, pathophysiology and therapy
- Péter Merész: HPLC-RP analysis of polyethylene glycol (PEG 400) for measuring intestinal permeability
- Zsófia Clemens: Intestinal permeability: causes and its relevance to autoimmune diseases and cancer
- Amber O’Hearn: Personal experiences in long-term carnivorous eating: benefits beyond carbohydrate restriction
- Thomas Seyfried: Cancer as a mitochondrial metabolic disease: Implications for novel therapeutics (online presentation)
- Zsófia Clemens: Combating cancer: Paleolithic ketogenic diet (PKD) as a stand-alone therapy. Theory, practice and results.
- Csaba Tóth: The paleolithic ketogenic diet (PKD) is more effective than medicines in treating chronic internal diseases. The art of tapering preexisting medicines.
- Ferenc Nagy – Mária Schimmer: Paleolithic ketogenic diet: perspective from the kitchen
- Zsófia Clemens: Paleo, low-carb, ketogenic, GAPS, AIP: Choose what you want?
- Károly Nagy: Raw meat feeding of dogs
- Gianluca Bosetti: Ketogenic diet and sports nutrition: the advantages of carbs periodization